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Objective:To explore the effect differences between moxibustion and donepezil hydrochloride on the attention network function of patients with mild cognitive impairment(MCI).rnMethods:A total of 64 patients of MCI were randomly divided into the moxibustion group and donepezil hydrochloride group,32 cases in each one.On the basis of conventional treatment,the patients in the moxibustion group were given moxibustion,6 times a week,and the patients in the donepezil hydrochlo-ride group were given donepezil hydrochloride orally,5 mg/day.The course of treatment was 60 days for both of the groups.Cognitive attention network function and activities of daily living(ADL)score were examined before and after treatment.rnResults:The differences of alerting reaction time(RT),executive control RT,overall mean RT and ac-curacy of the moxibustion group after treatment were significantly higher than those of the donepezil hydrochloride group[alert:(60.3 ± 3.3)ms vs(48.3 ± 3.7)ms,P ＜ 0.05;executive control:(81.2 ± 3.2)ms vs(91.7 ± 4.2)ms,P ＜ 0.05;total reaction time:(500.4 ± 17.2)ms vs(536.2 ± 20.1)ms,P ＜ 0.05;accuracy:(83.7 ± 4.6)％vs(77.4 ± 4.3)％,P ＜ 0.05].After treatment,the ADL scores of the both groups were significantly higher than those before treatment[the moxibustion group:(56.47±4.02)points vs(41.53±4.06)points,P ＜ 0.05;the donepezil hydrochloride group:(50.75±4.05)points vs(40.84±3.67)points,P ＜ 0.05],and the ADL score of the moxibustion group was significantly higher than that of the donepezil hydrochloride group[(56.47±4.02)points vs(50.75±4.05)points,P ＜ 0.05].rnConclusion:Compared with donepezil hydrochloride,moxibustion has a better effect on the cognitive function of MCI patients.