目的：观察奥氮平联合五氟利多治疗伴有顽固性幻听难治性精神分裂症的效果和安全性。方法以奥氮平联合五氟利多对60例既往使用氯氮平治疗的伴有顽固性幻听难治性精神分裂症患者进行为期12周的治疗，采用阳性和阴性症状量表（PANSS）评定疗效，以副反应量表（TESS）评定副反应。结果奥氮平联合五氟利治疗12周后显效率56．7%，有效率91．7%；无效8．3%。奥氮平联合五氟利多组的主要副反应为锥体外系反应9例，经对症处理后消失，其他不良反应相对少见共8例，包括恶心1例、便秘3例、头晕1例、口干2例、心动过速1例。不影响继续治疗。结论奥氮平联合五氟利多治疗伴有幻听慢性精神分裂症有良好疗效，且比氯氮平安全性高，患者对副作用耐受性良好。“,”Objective To observe the clinical efficacy and safety of olanzapine and penflouridol in the treatment of patients with schizophrenia. Methods A total of 60 patients with schizophrenia were treatmented olanzapine ang penflouridol for 12 weeks. The positive and negative symptoms scale(PANSS)was used to evaluated the efficacy,and the treatment emer_gent symptoms scale(TESS)was used to assess the side effects. Results The response rate were 91% for olanzapine ang pen_flouridol. The main side effects of olanzapine ang penflouridol were somnolence(9 case,17. 3% ),The prevalence of relatively rare adverse reactions was 15. 4%(8 case),which consisted of nausea(1 case),constipation(3 case),dizziness(1 case),dry mouth(2 case)and tachycardia(1 case). Conclusion Olanzapine and penflouridol are effective and safe in the treatment of schizophrenia.