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应用特异性较高的胰升糖素放免测定法,研究了正常人及Ⅱ型糖尿病患者的胰岛A细胞功能。正常人空腹血胰升糖素的平均值为132.8±65.0pg/ml。119例NIDDM患者空腹血胰升糖素平均值为192.9±129.6pg/ml。NIDDM患者不论是否采用胰岛素治疗,其血胰升糖素皆明显升高,提示胰岛A细胞对葡萄糖的敏感性降低。 7例男性正常人在静脉注射胰岛素(0.1U/kg)后,血胰升糖素平均增加114pg/ml,于30～60分钟达高峰。6例男性糖尿病患者中3例呈现反常的血胰升糖素反应降低,提示葡萄糖的平衡调节缺陷,并认为NIDDM患者的A细胞有功能缺陷。
The application of specific high glucagon radioimmunoassay, normal and type Ⅱ diabetes in patients with islet A cell function. The average fasting blood glucagon in normal people was 132.8 ± 65.0 pg / ml. The average fasting blood glucagon in 119 NIDDM patients was 192.9 ± 129.6 pg / ml. NIDDM patients with or without insulin therapy, the blood glucagon significantly increased, suggesting that islet A cell glucose sensitivity decreased. Seven patients with normal male insulin intravenous insulin (0.1U / kg), the average blood glucagon increased 114pg / ml, reached a peak in 30 to 60 minutes. Three of the six patients with diabetes mellitus showed an abnormal decrease in serum glucagon response, suggesting that glucose balance regulates defects and that A cells in NIDDM patients have functional defects.