目的：研究机体免疫功能的变化与恶性肿瘤发生及预后的关系。方法：采用ＭＴＴ比色法及双抗体夹心法对４２例胃癌、３５例乳腺癌、２８例大肠癌手术前后ＩＬ２及ｓＩＬ２Ｒ水平进行检测，并以健康献血员作对照。结果：３组恶性肿瘤患者术前ＩＬ２活性明显低于正常人；血清ｓＩＬ２Ｒ水平明显高于正常人。术后肿瘤复发患者ＩＬ２／ｓＩＬ２Ｒ水平持续异常；未复发患者ＩＬ２／ｓＩＬ２Ｒ水平恢复正常。结论：机体免疫功能的变化与恶性肿瘤的发生及预后密切相关 Objective: To study the relationship between the changes of immune function and the occurrence and prognosis of malignant tumor. Methods: The levels of IL2 and sIL2R in 42 cases of gastric cancer, 35 cases of breast cancer and 28 cases of colorectal cancer before and after operation were detected by MTT assay and double antibody sandwich method. Healthy blood donors were used as control. Results: The activity of IL2 before operation in 3 groups of malignant tumor patients was significantly lower than that in normal people. Serum sIL2R level was significantly higher than that in normal people. Postoperative tumor recurrence IL 2 / sIL 2R levels continued abnormalities; non-relapse patients IL 2 / sIL 2R levels returned to normal. Conclusion: The changes of immune function are closely related to the occurrence and prognosis of malignant tumor