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目的:观察益节健片对改善关节炎的功效。方法:通过人为造模,建立大鼠关节炎模型,分别给予蒸馏水、阳性对照药奥泰灵以及益节健片药液灌胃治疗。连续给药4周后处死动物,进行各项指标的测定。结果:益节健片对模型大鼠膝关节活动范围有明显的改善作用;益节健片各剂量组对模型大鼠膝关节滑膜厚度肿胀有抑制作用,能较好缓解关节的炎性症状,对制动后膝关节内滑膜及软骨的病理变化也有显著的改善作用。结论:益节健片对改善关节炎有一定的功效。
OBJECTIVE: To observe the effect of Yijianjian Tablet on improving arthritis. Methods: The model of arthritis in rats was established by artificial modeling, and distilled water and Oxytetrazol and Yi Jiao Jian Tablet were intragastrically administered respectively. Animals were sacrificed after 4 consecutive weeks of administration, and the determination of each index was carried out. Results: Yijianjian Tablet can significantly improve the range of knee joint activity in model rats. Yijianjian Tablet can inhibit the swelling of synovium of knee joint in model rats, and relieve the inflammatory symptoms , After the braking knee synovium and cartilage pathological changes also have a significant improvement. Conclusion: Yi Jiao Jian Tablet can improve arthritis to a certain extent.