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阿霉素为常用的抗肿瘤药,近年来应用阿霉素治疗三叉神经痛的文献报道较多,且已获得较好的效果,但其治疗机制尚不十分明确,尤其是对肌细胞及神经细胞的毒性作用机制特点及不同的给药方式和剂量选择尚不够明确。本文详细介绍了阿霉素对神经元及肌细胞毒性作用的机制和特点、作用的选择性和自限性以及不同给药方式产生的不同药理效应,显示出其在三叉神经痛、面肌痉挛等神经肌相关疾病发病机制研究及治疗方面的应用前景。
Adriamycin as a commonly used antineoplastic agents, in recent years, the application of doxorubicin in the treatment of trigeminal neuralgia reported in the literature more, and has achieved good results, but its mechanism of treatment is not yet clear, especially for muscle cells and nerves The mechanism of cell cytotoxicity and different modes of administration and dose selection are not yet clear enough. This article describes in detail the mechanism and characteristics of doxorubicin on neuronal and myocyte cytotoxicity, selectivity and self-limiting effect and different pharmacological effects produced by different modes of administration, And other neuromuscular diseases related to the pathogenesis of research and treatment of the application prospects.