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目的:观察“益肾疏肝汤”联合人工周期疗法治疗卵巢早衰肾虚肝郁证临床疗效。方法:卵巢早衰中医辨证肾虚肝郁证患者96例,治疗组62例,对照组34例。两组均采用口服补佳乐加黄体酮胶丸人工周期疗法治疗,治疗组同时口服“益肾疏肝汤”中药方剂。3个月1个疗程,共治疗2个疗程。观察治疗前后中医证候积分改变、血清FSH、E2水平改变及安全性指标。结果:两组治疗后治疗组中医证候平均改善率66.20%,对照组43.09%,差异有统计学意义(P<0.05);两组治疗后FSH、E2水平均有改善,差异有统计学意义(P<0.05);治疗组总有效率74.19%,对照组总有效率52.94%,差异有统计学意义(P<0.05)。结论:“益肾疏肝汤”联合人工周期疗法治疗卵巢早衰肾虚肝郁证疗效确切。
Objective: To observe the clinical efficacy of Yishen Shugan decoction combined with artificial cycle therapy in treatment of premature ovarian failure with kidney deficiency syndrome. Methods: 96 cases of TCM syndrome differentiation syndrome of kidney deficiency and stagnation syndrome, 62 cases of treatment group and 34 cases of control group. Both groups were treated with oral budesonide plus progesterone capsules artificial period therapy, the treatment group also oral “Yishen Shugan Tang ” prescription. 3 months 1 course of treatment, a total of 2 courses of treatment. Before and after treatment to observe changes in TCM syndrome scores, serum FSH, E2 levels and safety indicators. Results: The average improvement rate of TCM syndromes was 66.20% in the treatment group and 43.09% in the control group, with significant difference (P <0.05). The FSH and E2 levels in both groups were improved after treatment, with significant difference (P <0.05). The total effective rate was 74.19% in the treatment group and 52.94% in the control group, the difference was statistically significant (P <0.05). Conclusion: “Yishen Shugan decoction” combined with artificial cycle therapy in treatment of premature ovarian failure syndrome of stagnation of liver and liver has definite curative effect.