论文部分内容阅读
目的:观察津血源颗粒对干燥综合征模型大鼠的治疗作用。方法:采用差数离心法提取Lewis大鼠颌下腺的P5抗原,用其免疫Lewis大鼠。设津血源颗粒大剂量、小剂量组、模型组、空白对照组及佐剂组。动态观察各组大鼠唾液分泌量、饮水量、颌下腺指数、免疫器官指数及组织病理学。结果:模型组大鼠表现出唾液分泌量减少,饮水量增加,颌下腺指数、免疫器官指数、组织病理学淋巴细胞浸润程度较正常组明显增大。津血源颗粒对上述指标均有改善作用。结论:津血源颗粒对干燥综合征有治疗作用。
Objective: To observe the therapeutic effect of Jin Xue Yuan Granule on rats with Sjogren’s syndrome. Methods: The P5 antigen of submandibular gland of Lewis rats was extracted by differential centrifugation and used to immunize Lewis rats. Supplied Jin Xueyuan particles high-dose, low-dose group, model group, blank control group and adjuvant group. The salivary secretion, water intake, submandibular gland index, immune organ index and histopathology of rats in each group were dynamically observed. Results: The rats in the model group showed decreased salivary secretion and increased water intake. The submandibular gland index, immune organ index and histopathological lymphocytic infiltration were significantly increased in the model group compared with those in the normal group. Jin Xue Yuan particles on the above indicators have improved the role. Conclusion: Jin Xue Yuan Granules has a therapeutic effect on Sjogren’s syndrome.