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目的观察纳洛酮、醒脑静脉注射射液治疗急性脑梗死的疗效。方法将137例伴有意识障碍的急性脑梗死患者随机分为3组,联合组(纳洛酮+醒脑静)49例,单用纳洛酮组46例,单用醒脑静组42例。用药10d为1个疗程,对3组患者治疗后的意识状态好转的起效时间及10d、20d后神经功能缺损评分,临床疗效的总有效率进行比较。结果联合组意识状态好转的起效时间、神经功能缺损评分、临床疗效的总有效率均优于纳洛酮组及醒脑静组(P<0.05或P<0.01)。结论纳洛酮联合醒脑静脉注射射液治疗急性脑梗死比单用纳洛酮或醒脑静脉注射射液效果好,无明显不良反应。
Objective To observe the curative effect of Naloxone and Xingnao intravenous injection on acute cerebral infarction. Methods A total of 137 acute cerebral infarction patients with disturbance of consciousness were randomly divided into 3 groups: 49 cases in combination group (naloxone + xingnaojing), 46 cases in naloxone alone group and 42 cases in xingnaojing group alone. Medication 10d for a course of treatment, the improvement of the state of consciousness of the three groups after treatment onset time and 10d, 20d after neurological deficit score, the total effective rate of clinical efficacy were compared. Results The onset time, neurological deficit score and clinical efficacy in the combined group were better than naloxone group and Xingnaojing group (P <0.05 or P <0.01). Conclusion Naloxone combined with Xingnao intravenous injection for acute cerebral infarction than naloxone alone or reperfusion brain injection injection effect is good, no significant adverse reactions.