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胰岛功能受损是1型糖尿病的始动因素,也是2型糖尿病发病的中心环节。随着病程的进展,多种机制参与导致β细胞的功能进行性下降。如能够在早期及时发现β细胞的功能减退,并通过给予胰岛素强化治疗、钾通道开放剂、噻唑烷二酮类、血管紧张素转化酶抑制剂/血管紧张素受体Ⅰ拮抗剂、肠促胰岛素及类似物、二肽酶-Ⅳ抑制剂等药物及时有效地治疗以保护胰岛β细胞功能、促进胰岛再生,对糖尿病的防治具有重要意义。
Islet function impaired type 1 diabetes is the initiating factor, but also the incidence of type 2 diabetes. As the course of the disease progresses, multiple mechanisms contribute to the progressive decline of the function of the beta cells. Such as being able to detect β-cell dysfunction in an early and timely manner and by administering insulin potentiating therapies, potassium channel openers, thiazolidinediones, angiotensin converting enzyme inhibitors / angiotensin receptor type 1 antagonists, incretin And analogues, dipeptidyl-IV inhibitors and other drugs timely and effective treatment to protect the function of pancreatic β-cell and promote islet regeneration, prevention and treatment of diabetes is of great significance.