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目的 观察急性心肌梗塞（ＡＭＩ）患者静脉溶栓的临床疗效与心脏舒张功能关系。方法 选择接受静脉溶栓治疗的ＡＭＩ患者５０例，用ＨＰ２５００彩色多普勒超声心动图测定二尖瓣血流Ａ峰／Ｅ峰面积（ＶＡ／ＶＥ）、左室射血分数（ＬＶＥＦ）、短轴缩短率（ＦＳ），以及应用ＫｉｌｌｉＰ分级判定心功能。结果①３６例血管再通组与１４例未溶通组之间，在年龄、性别、ＡＭＩ部位、临床心功能、ＬＶＥＦ、ＦＳ以及高血压、糖尿病。陈旧心肌梗塞病史等方面均无显著差异（Ｐ＞ ０．０５）。②溶通组与未通组相比，ＶＡ／ＶＥ比值明显低于未通组（１．０１２９±０．３４２７比１．３３３５± ０．４０７７，Ｐ＜０．０１）；ＶＡ／ＶＥ＞１出现率少于未通组（４７．２％比８５．７％，Ｐ ＜ ０．０５）。结论 静脉溶栓治疗 ＡＭＩ使梗塞相关血管再灌注后，对左室舒张功能的保护作用可能会更大些。
Objective To observe the clinical efficacy of intravenous thrombolysis in patients with acute myocardial infarction (AMI) and its relationship with diastolic function. Methods Fifty patients with AMI undergoing intravenous thrombolysis were enrolled in this study. The peak area (AVE / VE), left ventricular ejection fraction (LVEF) and mitral inflow were measured by HP2500 color Doppler echocardiography Axis shortening (FS), and KilliP grading to determine cardiac function. Results ① There were no significant differences in age, gender, AMI, clinical cardiac function, LVEF, FS, hypertension and diabetes among 36 recanalization groups and 14 non-recanalization groups. Old myocardial infarction history no significant difference (P> 0.05). ② The ratio of VA / VE was significantly lower in patients in dissolvent group than those in unreasonable group (1.0129 ± 0.3427 vs 1.3335 ± 0.4077, P <0.01); VA / VE> 1 The incidence was lower than that of the failed group (47.2% vs 85.7%, P <0.05). Conclusion Intravenous thrombolytic therapy of AMI may make the protection of left ventricular diastolic function more likely after infarction-related vascular reperfusion.