论文部分内容阅读
抗生素和其它药物的微生物转化是七十年代以来逐步开拓的科研领域,与抗生素的生物合成、药物的化学合成及抗生素的半化学合成相比,有一定的特色。八十年代以来,抗生素的微生物转化已逐步成为提供高效、低毒的新型药物和改进一些重要药物复杂生产过程的新技术、新手段。迄今为止,氨基糖甙类、大环内酯类、蒽环类抗生素和其它一些药物均有文献报道其微生物转化方法,主要的转化反应有:氧
Microbial transformation of antibiotics and other drugs is a field of scientific research that has been gradually opened up since the 1970s and has certain characteristics compared with the biosynthesis of antibiotics, the chemical synthesis of drugs and the semi-chemical synthesis of antibiotics. Since the 1980s, microbial transformation of antibiotics has gradually become a new technique and new means of providing new drugs with high efficiency and low toxicity, as well as improving the complicated production process of some important drugs. So far, aminoglycosides, macrolides, anthracyclines and other drugs have been reported in the literature of microbial transformation methods, the main conversion reactions are: oxygen