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目的:探讨帕金森病(PD)患者外周血淋巴细胞(PBL)上多巴胺转运体(DAT)的表达。方法:应用免疫细胞化学法(ABC法)测定28例早期PD患者与13名健康对照者PBL上DAT的表达。结果:PD患者PBL上DAT的表达较健康对照显著下降,与病程呈负相关。多巴制剂的应用对PD患者DAT的表达无影响。结论:PD患者外周血淋巴细胞上存在DAT表达的异常。
Objective: To investigate the expression of dopamine transporter (DAT) on peripheral blood lymphocytes (PBL) in patients with Parkinson’s disease (PD). Methods: Immunohistochemistry (ABC method) was used to detect the expression of DAT on PBL in 28 early PD patients and 13 healthy controls. Results: The expression of DAT on PBL in PD patients was significantly lower than that in healthy controls, and negatively correlated with the course of disease. The application of dopa has no effect on the expression of DAT in PD patients. Conclusion: There is abnormal expression of DAT on peripheral blood lymphocytes in PD patients.