论文部分内容阅读
目的 :探讨淋巴细胞性胃炎 (LCG)的内镜、病理特点 ,以及根除幽门螺杆菌 (Hp)后对其的影响。方法 :分析 50例LCG的电子胃镜表现和病理所见 ,应用分级法评价淋巴细胞的浸润程度 ,应用PPI三联疗法根除Hp。结果 :LCG多见于中年男性 ,Hp感染率为84%。内镜特点 :90 %以上的病变位于胃窦和胃体的下段 ,特征性表现为多发性或弥漫性隆起样糜烂或脐样糜烂 ,共占 70 % ,可并发十二指肠球部病变 ,占 40 %。病理特点 :全部组织均有淋巴细胞浸润 ,淋巴滤泡形成占 58%。Hp根除后 ,41 .7%患者的胃镜表现胃黏膜大致正常 ;33 .3 %患者表现为黏膜稍充血水肿和花斑样改变 (P <0 .0 5) ;2 5%患者的糜烂灶明显减少 ,主要为散在的平坦性糜烂 (P <0 .0 5) ,而隆起样糜烂消失 ,淋巴滤泡完全消失 ;66.7%患者无淋巴细胞浸润 ,33 .3 %患者为 1级改变。根除Hp后 ,淋巴细胞分级为 0 .33± 0 .49级 (P <0 .0 0 1 )。结论 :LCG有一定的内镜和病理特点。根除Hp后 ,可明显减少淋巴细胞的浸润 ,且可治愈LCG。
Objective: To investigate the endoscopic and pathological features of lymphocytic gastritis (LCG) and its effect after eradication of Helicobacter pylori (Hp). Methods: 50 cases of LCG by endoscopy and pathological findings, the application of grading method to assess the degree of infiltration of lymphocytes, PPI triple therapy to eradicate Hp. Results: LCG more common in middle-aged men, Hp infection rate was 84%. Endoscopic features: more than 90% of lesions located in the lower antrum and gastric body, characterized by multiple or diffuse swelling or umbilical erosion erosion, a total of 70%, may be complicated by duodenal lesions, 40%. Pathological features: All tissues have lymphocytic infiltration, lymphoid follicles accounted for 58%. Gastroscopy in 41.7% of patients showed roughly normal gastric mucosa after eradication of Hp, 33.3% of patients showed mucosal congestion and edema (P <0.05), and 25% of patients had erosions (P <0. 05). However, the erosive erosions disappeared and the lymphatic follicles disappeared completely. There was no infiltration of lymphocytes in 66.7% of the patients, and grade 1 in 33.3% of the patients. After eradication of Hp, lymphocytes were graded as 0.33 ± 0.49 (P <0.001). Conclusion: LCG has some endoscopic and pathological features. After the eradication of Hp, can significantly reduce the infiltration of lymphocytes, and can cure LCG.