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目的探讨复方丹参滴丸联合卡托普利治疗糖尿病肾病患者的临床疗效。方法选取早期糖尿病肾病患者105例,按随机数字表法将其分为卡托普利组、复方丹参滴丸组、复方丹参滴丸和卡托普利组,各35例。比较3组患者的临床疗效。结果 3组患者的FBG、Hb A1c、Scr、BUN、Alb均低于治疗前,且复方丹参滴丸和卡托普利组患者的下降幅度均明显高于其他两组;复方丹参滴丸组和卡托普利组患者总有效率明显高于卡托普利组、复方丹参滴丸组,差异均有统计学意义;复方丹参滴丸联合卡托普利组较单用药物组改善更明显(均P<0.05)。结论复方丹参滴丸联合卡托普利治疗对延缓糖尿病肾病患者的进展、保护肾脏功能有积极的治疗意义。
Objective To investigate the clinical efficacy of compound Danshen dripping pills combined with captopril in patients with diabetic nephropathy. Methods 105 patients with early diabetic nephropathy were selected and divided into captopril group, compound Danshen dripping group, compound Danshen dripping pills and captopril group by random number table method, 35 cases each. The clinical efficacy of the three groups was compared. Results The FBG, Hb A1c, Scr, BUN and Alb in 3 groups were lower than those before treatment, and the declines in Fufang Danshen Diwan and Captopril were significantly higher than those in the other two groups. The total effective rate of patients in topiramate group was significantly higher than that in captopril group and compound Danshen dripping pills group, and the difference was statistically significant. Compound Danshen dripping pills combined with captopril group was more obvious than the single drug group P <0.05). Conclusion Compound Danshen dripping pills combined with captopril treatment of patients with delaying the progression of diabetic nephropathy, the protection of renal function has a positive therapeutic value.