吡哌酸(pipemidlc acid,PPA)是化学合成的吡酮酸类抗菌药物,我国于1981年正式投产并应用于临床。本品经临床试用表明,对急性和慢性尿路感染、细菌性痢疾、胆道感染、外科和呼吸道感染等均有明显疗效(总有效率92.4％),其中以急性尿路感染、急性细菌性痢疾疗效更为显著。近几年该药临床应用日趋广泛,不良反应也逐渐增多,有的反应甚为严重,现结合本组病例简介如下。 Pipemidic acid (pipemidic acid, PPA) is a chemically synthesized p-ketoacid antibacterial drug, which was officially put into operation in China in 1981 and applied to clinical practice. This product is clinically proven that acute and chronic urinary tract infections, bacillary dysentery, biliary tract infections, surgical and respiratory tract infections have significant effect (total effective rate 92.4%), of which acute urinary tract infection, acute bacterial dysentery The effect is more significant. In recent years, the clinical application of the drug is becoming more widespread, adverse reactions are gradually increasing, and some very serious reactions, is now combined with the case brief introduction is as follows.