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目的 :探讨糖尿病肾病患者血液高凝状态与蛋白尿的关系。方法 :5 7例糖尿病肾病患者 ,以 2 4h尿蛋白定量分为高 (H)、中 (M )和低 (L)三组。并对其中 17例实施 8个月的华法令治疗。系统检测凝血、纤溶及肾功能指标。结果 :伴随尿蛋白量增多 ,凝血活性进一步亢进 ;但华法令改善高凝状态后 ,尿蛋白并无改善。结论 :血液高凝状态伴随糖尿病肾病患者蛋白尿出现而形成 ,并因此逐渐加重。
Objective: To investigate the relationship between blood hypercoagulability and proteinuria in patients with diabetic nephropathy. Methods: Fifty-seven patients with diabetic nephropathy were divided into high (H), medium (M) and low (L) groups with 24 h urinary protein. 17 of them were treated with warfarin for 8 months. System testing coagulation, fibrinolysis and renal function indicators. Results: Accompanied by an increase in urinary protein, coagulation activity was further increased; however, urinary protein did not improve after warfarin was given to hypercoagulable state. Conclusion: Hypercoagulable state of blood accompanies the appearance of proteinuria in patients with diabetic nephropathy, and thus gradually aggravates.