论文部分内容阅读
目的：观察石斛夜光颗粒剂对大鼠实验性白内障的形成和家兔球结膜微循环的影响。方法：将１２０只大鼠随机分为对照组，模型组和丸药组，其中丸药组又分为大剂量组，中剂量组和小剂量组。分别记录实验开始后第１０天、第１５天和第２０天晶状体的混浊程度。将３２只家兔随机分为对照组、大剂量组、小剂量组和丸药组。灌胃给药６０ｍｉｎ后经耳静脉注射１０％高分子右旋糖酐６ｍｌ／ｋｇ，观察球结膜血管的改变。结果：大鼠实验性白内障的发生率在模型组、丸药组和大、中剂量组中分别为３３３％～６６７％、３６４％～６３６％和２７３％～７２７％，组间比较有显著差异（Ｐ＜００５）；在大中小剂量组中分别为２７３％～７２７％、３３３％～６６７％和４１７％～５８３％。家兔球结膜微循环观察显示在血液颜色、血流形态、血管口径、毛细血管交叉点数方面，各组间均有显著差异（Ｐ＜００５）。结论：石斛夜光颗粒剂具有延缓大鼠实验性白内障形成和改善家兔球结膜微循环的作用。
Objective: To observe the effects of Shiqi luminous granules on the formation of experimental cataract in rats and microcirculation of rabbit conjunctiva. Methods: 120 rats were randomly divided into control group, model group and bolus group. The bolus group was divided into high dose group, medium dose group and low dose group. The degrees of turbidity of the lens on the 10th, 15th, and 20th days after the start of the experiment were recorded. Thirty-two rabbits were randomly divided into control group, large dose group, small dose group and pill group. After intragastric administration for 60 minutes, 10% of polymer dextran 6ml/kg was injected into the ear vein to observe the change of conjunctival blood vessels. RESULTS: The incidence of experimental cataract in rats was 33.3% to 66.7%, 36.4% to 63.6%, and 27% to 3% in the model group, the pill group, and the large and middle dose groups, respectively. 72.7%, there was a significant difference between the groups (P <0. 05); in the large, medium and small dose groups, they were 27.3% to 72.7%, 33.6% to 66.7% and 41.7% respectively. %~583%. The observation of rabbit conjunctival microcirculation showed that there were significant differences among the groups in blood color, blood flow morphology, blood vessel caliber, and number of capillary cross points (P < 0.05). Conclusion: Shiqi luminous granules can delay the experimental cataract formation and improve the microcirculation of rabbit conjunctiva.