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目的:探讨人类乳腺癌血清中VEGF-C和FLT-4的表达与乳腺癌淋巴结转移的关系。方法:采用ELISA方法对75例乳腺癌患者和30例乳腺良性肿瘤患者的血清进行VEGF-C和FLT-4水平的检测。结果:乳腺癌组VEGF-C表达水平为(788.13±40.09)pg/ml,高于乳腺良性肿瘤组的(317.35±43.26)pg/ml,乳腺癌组FLT-4水平为(564.39±67.06)pg/ml,高于乳腺良性肿瘤组的(353.62±58.47)pg/ml,差异均有统计学意义(P<0.05);有淋巴结转移乳腺癌患者VEGF-C浓度为(1054.26±215.48)pg/ml,FLT-4浓度为(730.45±142.87)pg/ml,高于无淋巴结转移乳腺癌患者,差异有统计学意义(P<0.05);手术后2周乳腺癌患者VEGF-C和FLT-4浓度分别为(362.41±97.65)pg/ml、(324.58±76.54)pg/ml,低于术前水平,差异有统计学意义(P<0.05)。结论:检测VEGF-C和FLT-4水平可以辅助判断乳腺癌淋巴结转移情况。
Objective: To investigate the relationship between the expression of VEGF-C and FLT-4 in human breast cancer and lymph node metastasis of breast cancer. Methods: The serum levels of VEGF-C and FLT-4 in 75 patients with breast cancer and 30 patients with benign breast tumor were detected by ELISA. Results: The expression of VEGF-C in breast cancer group was (788.13 ± 40.09) pg / ml, which was higher than that in benign breast tumor group (317.35 ± 43.26) pg / ml. The FLT-4 level in breast cancer group was 564.39 ± 67.06 pg / ml, which was significantly higher than that of benign breast tumor (353.62 ± 58.47) pg / ml (P <0.05). The VEGF-C concentration of breast cancer with lymph node metastasis was (1054.26 ± 215.48) pg / ml , And the level of FLT-4 was (730.45 ± 142.87) pg / ml, which was significantly higher than that in patients without lymph node metastasis (P <0.05). The levels of VEGF-C and FLT- (362.41 ± 97.65) pg / ml and (324.58 ± 76.54) pg / ml, respectively, which were lower than preoperative levels, the difference was statistically significant (P <0.05). Conclusion: Detecting the levels of VEGF-C and FLT-4 may be helpful in judging the lymph node metastasis of breast cancer.