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目的探讨内蒙古汉族人群硒蛋白S(SelS)基因单核苷酸多态性(SNP)与胃癌发病风险的关联性。方法采用PCR-RFLP技术对133例内蒙古汉族胃癌患者及135例体检健康对照者进行SelS基因分型,并经测序验证结果。采用SPSS17.0分析SelS基因SNP rs34713741与胃癌发病风险的相关性。结果 SelS基因SNP rs34713741基因型CC、CT、TT及等位基因C、T在胃癌组和健康对照组间差异有统计学意义(分别为6.105、6.294,P均<0.05)。内蒙古汉族人群中携带T等位基因的CT/TT个体患胃癌的风险是CC基因型个体的1.57倍(OR=1.570,95%CI:1.084~2.274);携带T等位基因且吸烟的个体患胃癌的风险增加,是CC基因型的2.216倍(OR=2.216,95%CI:1.530~3.209)。结论 SelS基因SNP rs34713741与内蒙古汉族人群胃癌的发病具有相关性,T等位基因可能是胃癌发病的危险因素之一,吸烟可增加发病的风险。
Objective To investigate the association between single nucleotide polymorphisms (SNPs) of selenoprotein S (SelS) and the risk of gastric cancer in Han nationality in Inner Mongolia. Methods A total of 133 gastric cancer patients in Inner Mongolia and 135 healthy controls were genotyped by PCR-RFLP and sequenced. The association between SelS gene SNP rs34713741 and the risk of gastric cancer was analyzed by SPSS17.0. Results The genotypes CC, CT, TT and allele C, T of SNP rs34713741 of SelS gene were significantly different between gastric cancer group and healthy control group (6.105,6.294, P <0.05 respectively). The risk of gastric cancer in CT / TT individuals with T allele in Inner Mongolia Han population was 1.57 times that of individuals with CC genotype (OR = 1.570, 95% CI: 1.084-2.274); individuals with T allele and smoking The risk of gastric cancer increased 2.216 times that of the CC genotype (OR = 2.216, 95% CI: 1.530-3.209). Conclusion The SNP rs34713741 of SelS gene is correlated with the incidence of gastric cancer in Han population of Inner Mongolia. T allele may be one of the risk factors of gastric cancer. Smoking may increase the risk of gastric cancer.