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目的了解自身免疫性风湿病患者血清中两种可溶性黏附分子(sAM)——可溶性细胞间黏附分子-1(sICAM-1)和可溶性选择素E(sE-selectin)的水平,并揭示两种sAM与临床病情的关系。方法采用酶联免疫吸附试验(ELISA)检测三种自身免疫性风湿病系统性红斑狼疮(SLE)、类风湿关节炎(RA)、多发性肌炎/皮肌炎(PM/DM)患者,30例非自身免疫性风湿病患者及20名健康对照血清中sICAM-1、sE-selectin的含量,并分析两种sAM与临床资料、实验室检测指标的相关性。结果所测自身免疫性风湿病患者(包括3个组)血清中sICAM-1、sE-selectin水平较非自身免疫性风湿病及正常对照组明显增高(P<0.05)。RA组患者血清中sICAM-1与类风湿因子(RF)呈正相关。PM/DM组患者血清sE-selectin水平与肌酸激酶(CK)值呈正相关。结论本研究结果表明,sICAM-1和sE-selectin参与了自身免疫性风湿病的发病过程。异常升高的sICAM-1、sE-selectin水平可反映某些类型的自身免疫性风湿病(RA、PM/DM)的活动程度。
Objective To investigate the levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble selectin E (sE-selectin) in sera of patients with autoimmune rheumatism and to reveal the relationship between two sAM Relationship with clinical condition. Methods Three kinds of autoimmune rheumatism patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and polymyositis / dermatomyositis (PM / DM) were detected by enzyme-linked immunosorbent assay (ELISA) Cases of non-autoimmune rheumatic disease and 20 healthy control serum sICAM-1, sE-selectin levels, and analysis of two sAM and clinical data, laboratory test indicators correlation. Results The levels of sICAM-1 and sE-selectin in serum of patients with autoimmune rheumatism (including three groups) were significantly higher than those of non-autoimmune rheumatism and normal controls (P <0.05). Serum levels of sICAM-1 and rheumatoid factor (RF) in RA patients were positively correlated. Serum sE-selectin levels in patients with PM / DM were positively correlated with creatine kinase (CK). Conclusion The results of this study indicate that sICAM-1 and sE-selectin are involved in the pathogenesis of autoimmune rheumatism. Abnormally elevated levels of sICAM-1 and sE-selectin may reflect the degree of activity of some types of autoimmune rheumatism (RA, PM / DM).