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为探讨甲状腺功能改变对骨代谢的影响 ,对 91例甲亢 ,37例甲减及 5 1名健康对照者用免疫放射 (IR MA)法测骨钙素 (BGP)及甲状旁腺素 (PTH) ,用镅 - 2 41单光子跟骨密度仪测骨密度 (BMD)。结果发现 ,BGP含量 :甲亢组明显高于对照组 (P <0 .0 0 1) ,甲减组明显低于对照组 (P <0 .0 0 1) ;PTH含量 :甲亢组低于对照组 (P <0 .0 5 ) ,甲减组明显高于对照组 (P <0 .0 0 1) ;骨密度测定 :甲亢与甲减组骨质疏松发病率均明显高于对照组 (P <0 .0 0 1)。甲亢与甲减组骨质疏松发病年龄前移 ,甲减组 5 5岁以上都有骨质疏松。BGP和PTH改变明显早于骨密度变化 ,可作为甲状腺功能异常时骨代谢变化的灵敏指标 ,特别用于疗效观察
To investigate the effect of thyroid function changes on bone metabolism, 91 cases of hyperthyroidism, 37 cases of hypothyroidism and 51 healthy controls were measured by IR (radioimmunoassay) for BGP and PTH, , Using 镅 - 2 41 single photon calcaneus density measurement of bone mineral density (BMD). The results showed that BGP content in hyperthyroidism group was significantly higher than that in control group (P <0.01), hypothyroidism group was significantly lower than that in control group (P <0.01); PTH content was lower in hyperthyroidism group than in control group (P <0.05). The hypothyroidism group was significantly higher than that of the control group (P <0.01). The bone mineral density of hyperthyroidism and hypothyroidism group were significantly higher than that of the control group (P < 0 .0 0 1). Hyperthyroidism and hypothyroidism osteoporosis age of onset of advancement, hypothyroidism over the age of 5 have osteoporosis. BGP and PTH changes significantly earlier than changes in bone mineral density can be used as a sensitive indicator of bone metabolism changes in abnormal thyroid function, especially for the efficacy of observation