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目的 :研究中药复方制剂冠心灵的心血管作用并初步探讨其作用机制。方法 :运用细胞内微电极技术、L angendorff离体心脏灌流和心率变异性功率谱分析等方法 ,研究冠心灵对心肌细胞动作电位的影响 ;观察其对冠脉血流量和心肌收缩力的作用 ;分析冠心灵对冠心病患者心率变异性的影响。结果 :冠心灵增强 Ca2 +跨膜内流 ;增加冠脉血流量和心肌收缩力 ;改善因缺血导致冠脉流量和心肌收缩力的下降 ;功率谱分析显示心迷走交感对心率的调控作用比升高。结论 :冠心灵有改善心肌缺血的作用。
Objective : To study the cardiovascular effects of Guanxin, a traditional Chinese medicine compound preparation, and to explore its mechanism of action. METHODS: The effect of coronary nucleus on action potential of cardiomyocytes was studied by intracellular microelectrode technique, isolated heart perfusion with Langendorff and power spectrum analysis of heart rate variability. The effects of coronary sinus on coronary blood flow and myocardial contractility were observed. To analyze the influence of crown mind on heart rate variability in patients with coronary heart disease. RESULTS: Coronary nucleus enhanced Ca2 + transmembrane influx; increased coronary blood flow and cardiac contractility; improved coronary flow and decreased myocardial contractility due to ischemia; power spectrum analysis showed that heart vagus sympathetic regulative effects on heart rate Increased. Conclusion: Coronary heart has the effect of improving myocardial ischemia.