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生物体内氧自由基的致病作用已渐被人们所认识。因此,作为体内氧自由基清除剂的超氧化物歧化酶(SOD)在疾病发生和发展过程中的变化,以及应用外源性SOD治疗疾病已受到广泛的重视。本文应用放射免疫法对20例次维持性血液透析(HD)治疗的尿毒症患者HD过程中全血铜锌超氧化物歧化酶(SOD-1)含量进行了动态检测,以探索氧自由基和SOD-1在尿毒症疾病过程中的意义及HD的影响。材料与方法 1.尿毒症组:6例,男女各3例。年龄37～
The role of oxygen free radicals in vivo pathogenesis has gradually been recognized. Therefore, the changes of superoxide dismutase (SOD) as an oxygen free radical scavenger in vivo during the development and progression of the disease, and the application of exogenous SOD in the treatment of diseases have received extensive attention. In this paper, the content of copper-zinc-superoxide dismutase (SOD-1) in whole blood of patients with uremia treated by subcutaneous maintenance hemodialysis (HD) was tested by radioimmunoassay in order to explore the effects of oxygen free radical and The significance of SOD-1 in uremic disease and the influence of HD. Materials and methods 1. uremia group: 6 cases, 3 cases of male and female. Age 37 ~