Objective To investigate the clinical and pathological characteristics of primary cervical malignant melanoma, and its prognosis. Methods The clinical and pathological data of four patients with primary malignant melanoma of the cervix were an-alyzed retrospectively. Nerve tissue protein S-100 and monoclonal antibody to melanoma (HMB-45) were measured in all cases by immunohistochemical method. All four patients received radical hysterectomy. Three of them received chem-otherapy preoperation or postoperation, and one of them received biotherapy with interferon-γ and interleukin-2 at the same time. All the cases were followed up. Results The average age of four patients was 45 years. Clinical symptoms presented with irregular vaginal bleeding,postcoital bleeding, or increase of vaginal discharge. Gynecologic examination showed polypus papilla cauliflower-shaped ornodulated black-brown or black-blue mass on the cervix. All the four cases were pathologically diagnosed with cervical ma-lignant melanoma. S-100 and HMB-45 were positive in all patients. Two patients died at 6 and 41 months postoperation, res-pectively. The other two patients survived for 3.5 and 7 years postoperation, respectively. Conclusions S-100 protein and HMB-45 play very important roles in the diagnosis of primary malignant melanoma ofcervix. Radical hysterectomy, chemotherapy combined with dimethyl triazemo imidazole carboxamide and biological therapies may improve the prognosis of the primary malignant melanoma of cervix if the disease could be diagnosed in an early stage. Objective To investigate the clinical and pathological characteristics of primary cervical malignant melanoma, and its prognosis. Methods The clinical and pathological data of four patients with primary malignant melanoma of the cervix were an-alyzed retrospectively. Nerve tissue protein S-100 and monoclonal antibody to All four patients received radical hysterectomy. Three of them received chemotherapy-preoperation or postoperation, and one of them received biotherapy with interferon-gamma and interleukin-2 at the same Results The average age of four patients was 45 years. Clinical symptoms presented with irregular vaginal bleeding, postcoital bleeding, or increase of vaginal discharge. Gynecologic examination showed polypus papilla cauliflower-shaped ornodulated black-brown or black-blue mass on the cervix. All the four cases were pathologically diagnosed with cervical ma-li Two patients died at 6 and 41 months postoperation, res-pectively. The other two patients survived for 3.5 and 7 years postoperation, respectively. Conclusions S-100 protein and HMB-45 play very important roles in the diagnosis of primary malignant melanoma ofcervix. Radical hysterectomy, chemotherapy combined with dimethyl triazemo imidazole carboxamide and biological therapies may improve the prognosis of the primary malignant melanoma of cervix if the disease could be diagnosed in an early stage .