目的评估冷冻消融对Ⅲ/Ⅳ期原发性肝癌患者肝功能的损害情况。方法前瞻性研究21例Ⅲ/Ⅳ期原发性肝癌患者冷冻消融前后肝功能各项指标的变化,进行统计学分析。结果在冷冻消融后,总胆红素(TB IL)、直接胆红素(DB IL)、间接胆红素(IB IL)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、谷酰转肽酶(GGT)及总胆汁酸(TBA)均较冷冻前升高,总蛋白(TP)、白蛋白(ALB)、胆碱酯酶(CHE)在冷冻后下降,其中总胆红素、白蛋白、胆碱酯酶的冷冻前后变化差异有显著性(P<0.05,P<0.05,P<0.01)。结论冷冻消融治疗对Ⅲ/Ⅳ期原发性肝癌患者肝功能具有一定损害,应严格把握治疗适应证。 Objective To assess the damage of liver function in patients with stage Ⅲ / Ⅳ hepatocellular carcinoma by cryoablation. Methods The prospective study of 21 patients with stage Ⅲ / Ⅳ hepatocellular carcinoma before and after cryoablation of liver function changes in various indicators for statistical analysis. Results After cryoablation, total bilirubin, DB IL, IB IL, ALT, AST, ALP, (ALP), glutamyl transpeptidase (GGT) and total bile acid (TBA) were higher than those before freezing, and the total protein (TP), albumin (ALB) and cholinesterase (CHE) There was significant difference in total bilirubin, albumin and cholinesterase before and after freezing (P <0.05, P <0.05, P <0.01). Conclusion Cryoablation has some damage to the liver function of patients with stage Ⅲ / Ⅳ hepatocellular carcinoma, indications should be strictly controlled.