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目的探讨白细胞介素-6(Interleukin-6,IL-6)在小儿全身炎症反应综合症(systemic inflammatory response Syndrome,SIRS)过程中所起的作用和临床意义。方法30例小儿SIRS患者为SIRS组,30例门诊普通发热儿童为发热对照组,另外30例门诊正常体检儿童为健康对照组,采用ELISA法测定受检者血清IL-6含量。结果实验组患儿血清IL-6含量显著高于发热对照组和健康对照组,而发热对照组和健康对照组的IL-6含量无显著性差异。结论IL-6参与了小儿全身炎症反应综合症(SIRS)的发生发展,IL-6的含量测定可作为SIRS的辅助诊断指标。
Objective To investigate the role and clinical significance of Interleukin-6 (IL-6) in the process of systemic inflammatory response syndrome (SIRS) in children. Methods Thirty children with SIRS were selected as SIRS group. Thirty children with normal fever in outpatient setting as fever control group. The other 30 children with normal physical examination were selected as healthy control group. Serum IL-6 level was measured by ELISA. Results The content of IL-6 in experimental group was significantly higher than that in fever control group and healthy control group, while there was no significant difference in IL-6 content between fever control group and healthy control group. Conclusion IL-6 is involved in the pathogenesis and development of systemic inflammatory response syndrome (SIRS) in children. The determination of IL-6 can be used as a diagnostic indicator of SIRS.