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目的探讨早期胰岛素强化治疗对初诊2型糖尿病(T2DM)患者胰岛功能的影响。方法 56例初诊2型糖尿病患者,餐前胰岛素加基础胰岛素强化治疗,分析对比治疗前后空腹、餐后30、120 min静脉血糖、C-肽/胰高血糖素变化情况。结果强化治疗前后比较,各时点静脉血糖、C-肽/胰高血糖素比C-肽曲线下面积、胰高血糖素曲线面积、HOMA-IR指数比较差异均有统计学意义(P<0.05)。结论早期胰岛素强化治疗能够明显改善初诊2型糖尿病患者β细胞、α细胞功能,临床应用价值较高。
Objective To investigate the effect of early intensive insulin therapy on islet function in newly diagnosed type 2 diabetes mellitus (T2DM). Methods Fifty - six patients with newly diagnosed type 2 diabetes mellitus (T2DM) were enrolled in this study. Pre - and post - prandial insulin plus basal insulin was intensively treated. The changes of fasting blood glucose and C - peptide / glucagon at 30 and 120 min after meal were analyzed. Results Before and after intensive treatment, the differences of venous blood glucose, C-peptide / C-peptide area under curve, glucagon curve area and HOMA-IR index at each time point were statistically significant (P <0.05 ). Conclusions Early intensive insulin therapy can significantly improve β-cell and α-cell function in newly diagnosed type 2 diabetic patients and has high clinical value.