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冠脉粥样硬化症的缺血发作不能预测,与病变的严重程度也无线性关系。5-羟色胺(5-HT)是血小板凝聚的主要产品。动物模型发现它的作用可由于内皮细胞脱落或动脉硬化而加强。它与另一血小板衍化物血栓素A_2有协同作用。 为了研究冠心病人冠脉对5-HT的反应如何,作者对无冠心病者测试冠脉内输注5-HT时分段剂量—反应曲线。并与冠心病伴稳定型心绞痛者相比较,还比较了稳定型心绞痛与变异型心绞痛病人输注5-HT对冠脉各节段上的作用。进行心导管术前均先测运动试验及非侵入性促发试验(静注麦角新硷) 将22例准备行心导管术的病人分成3组,第1组包括8例非典型胸痛。运动试验及促发试验结果阴性;冠脉造影正常者作为对照组。第2组包括9
Coronary atherosclerosis ischemic attack can not be predicted, and the severity of the disease has no linear relationship. Serotonin (5-HT) is a major product of platelet aggregation. Animal models found that its role may be due to endothelial cell shedding or atherosclerosis and strengthened. It synergizes with another platelet derivative thromboxane A_2. To investigate coronary artery response to 5-HT in patients with coronary artery disease, we performed a sub-dose-response curve of 5-HT intracoronary infusion in patients without coronary heart disease. Compared with patients with coronary heart disease and stable angina pectoris, the effects of 5-HT infusion on coronary segments in patients with stable angina pectoris and variant angina pectoris were also compared. Precardiac exercise tests and noninvasive trigger tests (intravenous ergomethine) were performed prior to cardiac catheterization. Twenty-two patients undergoing cardiac catheterization were divided into three groups. Group 1 included 8 atypical chest pain. Exercise test and test results were negative; normal coronary angiography as a control group. Group 2 includes 9