Hydrological monitoring and seasonal forecasting is an active research field because of its potential applications in hydrological risk assessment, preparedness and mitigation. In recent decades, developments in ground and satellite measurements have made the hydrometeorological information readily available, and advances in information technology have facilitated the data analysis in a real-time manner. New progress in climate research and modeling has enabled the prediction of seasonal climate with reasonable accuracy and increased resolution. These emerging techniques and advances have enabled more timely acquisition of accurate hydrological fluxes and status, and earlier warning of extreme hydrological events such as droughts and floods. This paper gives current state-of-the-art understanding of the uncertainties in hydrological monitoring and forecasting, reviews the efforts and progress in operational hydrological monitoring system assisted by observations from various sources and experimental seasonal hydrological forecasting, and briefly introduces the current monitoring and forecasting practices in China. The grand challenges and perspectives for the near future are also discussed, including acquiring and extracting reliable information for monitoring and forecasting, predicting realistic hydrological fluxes and states in the river basin being significantly altered by human activity, and filling the gap between numerical models and the end user. We highlight the importance of understanding the needs of the operational water management and the priority to transfer research knowledge to decision-makers. Hydrological monitoring and seasonal forecasting is an active research field because of its potential applications in hydrological risk assessment, preparedness and mitigation. In recent decades, developments in ground and satellite measurements have made the hydrometeorological information readily available, and advances in information technology have facilitated the data analysis in a real-time manner. New progress in climate research and modeling has enabled the prediction of seasonal climate with reasonable accuracy and increased resolution. These emerging techniques and advances have enabled more timely acquisition of accurate hydrological fluxes and status, and earlier warning of extreme hydrological events such as droughts and floods. This paper gives current state-of-the-art understanding of the uncertainties in hydrological monitoring and forecasting, reviews the efforts and progress in operational hydrological monitoring system assisted by observations from various sources an d experimental seasonal hydrological forecasting, and briefly introduces the current monitoring and forecasting practices in China. The grand challenges and perspectives for the near future are also discussed, including acquiring and extracting reliable information for monitoring and forecasting, predicting realistic hydrological fluxes and states in the river basin being significantly altered by human activity, and filling the gap between numerical models and the end user. We highlight the importance of understanding the needs of the operational water management and the priority to transfer research knowledge to decision-makers.