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目的:探讨变异型Richter综合征的临床特点、治疗与预后。方法:报道1例变异型Richter综合征,通过病理组织学、骨髓细胞学、细胞化学及免疫组织化学方法研究该病的临床、骨髓细胞形态学与病理变化,结合文献复习,探讨其发病机制、诊断、治疗与预后特点。结果与结论:患者为64岁女性,首发症状为左腋下无痛性淋巴结肿大,淋巴结组织活组织检查诊断为霍奇金淋巴瘤;骨髓穿刺结果为慢性T细胞淋巴细胞白血病,经多种方案化学治疗,仅存活8个月。该例霍奇金淋巴瘤并发慢性淋巴细胞白血病,即变异型Richter综合征,临床非常少见,其预后不良。
Objective: To investigate the clinical features, treatment and prognosis of variant Richter syndrome. Methods: One case of variant Richter syndrome was reported. The clinical and myeloid cell morphology and pathological changes of the disease were studied by histopathology, myelocytology, cytochemistry and immunohistochemistry. Combined with literature review, the pathogenesis, Diagnosis, treatment and prognosis. RESULTS AND CONCLUSION: The patient was 64 years old. The first symptom was painless lymphadenopathy of the left armpit, the diagnosis of Hodgkin’s lymphoma by lymph node tissue biopsy, and the result of bone marrow as chronic T-cell lymphocytic leukemia. Program chemotherapy, survived only 8 months. The case of Hodgkin’s lymphoma complicated with chronic lymphocytic leukemia, that is, variant Richter syndrome, clinical rare, the prognosis is poor.