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目的:研究治咳川贝枇杷滴丸对豚鼠的镇咳、平喘作用。方法:采用豚鼠离体气管平滑肌收缩实验和组胺引喘的活体动物实验对治咳川贝枇杷滴丸的平喘作用进行评价。在离体实验中测定药物对乙酰胆碱引起的气管平滑肌收缩的收缩曲线,计算收缩百分率;在整体动物实验中测定给药后豚鼠的延喘时间用来表征药物平喘作用的强弱。同时采用枸橼酸诱发豚鼠咳嗽模型,通过记录引咳后5min内的咳嗽次数,观察治咳川贝枇杷滴丸的镇咳作用。结果:治咳川贝枇杷滴丸能有效减少豚鼠的咳嗽次数,显著延长咳嗽潜伏期;对豚鼠离体气管收缩的抑制效果较好;对组胺致喘豚鼠的哮喘潜伏期有明显的延长作用。结论:治咳川贝枇杷滴丸具有良好的镇咳、平喘药理活性,为药物的临床应用和进一步开发提供了依据。
Objective: To study the antitussive and antiasthmatic effects of Cough and Chuanbei loquat drop pills on guinea pigs. Methods: The anti-asthmatic effect of Zhikukuanbei loquat dripping pill was evaluated by in vitro experiments of guinea pig tracheal smooth muscle contraction and histamine asthma. In vitro experiments to determine acetylcholine-induced contraction of tracheal smooth muscle contraction curve, calculate the percentage of contraction; determination of the overall animal experiments Guinea pigs after the treatment of the delay time used to characterize the strength of drug antiasthmatic effect. At the same time citrate-induced guinea pig cough model, by recording the number of cough within 5min after cited cough, observed cough Chuanbei loquat drop pills antitussive effect. Results: Cough Chuanbei loquat drop pills can effectively reduce the number of cough in guinea pigs, significantly prolong the latent period of cough; guinea pig tracheal contraction inhibition effect is good; histamine induced asthma Guinea pigs significantly delayed the incubation period. Conclusion: Cough Chuanbei loquat drop pills have good antitussive and antiasthmatic pharmacological activities, which provide the basis for the clinical application and further development of the drugs.