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目的 探讨 9 顺维甲酸 ( 9 cis RA)对肺鳞癌细胞的生物学作用。方法 对应用 9 cis RA处理后L78和A2 两肺鳞癌细胞株的生长、分化和凋亡等特性进行检测观察。结果 ① 9 cis RA对两肺癌细胞株的生长产生明显的抑制作用 ;②应用 9 cis RA后 ,两株细胞分化特征明显 ;③经 9 cis RA处理后的两肺鳞癌细胞凋亡率明显高于对照组。结论 9 cis RA具有抑制肺鳞癌细胞的生长、诱导其分化和凋亡等生物学作用。
Objective To investigate the biological effects of 9 cis RA on lung squamous carcinoma cells. Methods The growth, differentiation and apoptosis of L78 and A2 lung squamous cell carcinoma cell lines treated with 9 cis RA were detected. Results 9 cis RA significantly inhibited the growth of lung cancer cell lines. 2 After 9 cis RA, the two cells differentiated significantly. 3 The apoptosis rates of both lung squamous cell carcinoma cells treated with 9 cis RA were significantly higher. In the control group. Conclusion 9 cis RA has biological effects such as inhibiting the growth of lung squamous cell carcinoma, inducing its differentiation and apoptosis.