皮肤利什曼病(CL)的全身治疗注射药物有五价锑化合物及酮康唑,其价格昂贵和/或有毒副作用,广泛应用受限。口服硫酸锌(ZnSO_4)是皮肤病科常用疗法,近有报道硫酸锌局部治疗CL病灶效果良好,本研究观察硫酸锌对旧大陆两种利什曼原虫体外培养的敏感性及动物模型口服硫酸锌的治疗和预防效果。 硕大利什曼原虫和热带利什曼原虫的前鞭毛体和无鞭毛体用Al-Bashir(1992)培养 Systemic Treatment of Cutaneous Leishmaniasis (CL) Injectable drugs are pentavalent antimony compounds and ketoconazole, which are expensive and / or toxic and have limited application. Oral zinc sulfate (ZnSO 4) is a commonly used therapies for dermatology. It has been reported that the local treatment of zinc sulfate has a good effect on CL lesions. In this study, we observed the sensitivity of zinc sulfate to culturing two Leishmania species in the old continent and the animal model of oral zinc sulfate Therapeutic and preventive effects. Prophase and amastigotes of Leishmania major and Leishmania tropicae were cultured with Al-Bashir (1992)