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目的 观察食管癌高发区人群各种食管癌前疾患及食管癌组织中p5 3蛋白的表达并探讨其可能的机制。方法 应用免疫组化方法检测 2 18例食管不同阶段病变 (基底细胞增生、不典型增生、食管癌 )中p5 3的表达。结果 p5 3阳性表达检出率 ,在基底细胞增生为 41 84% ,不典型增生为 73 85 % ,食管癌为 75 %。基底细胞增生病例中有 86 44%为“ +”阳性 ,不典型增生病例“ +”阳性占5 8 33 % ,“ + +”以上阳性占 41 6 7% ,食管癌病例中p5 3表达水平均在“ + +”以上 ,且 5 5 5 6 %的病例为“ + + + +”阳性强表达。结论 在食管癌前病变期特别是良性增生阶段就存在p5 3蛋白的表达 ,这可能是由于损伤诱导的细胞内野生型p5 3蛋白表达 ,不可将p5 3蛋白的阳性表达均视为恶性转化的必然趋势。
Objective To investigate the expression of p5 3 protein in esophageal precancerous lesions and esophageal carcinoma in high risk area of esophageal cancer and to explore its possible mechanism. Methods Immunohistochemistry was used to detect the expression of p5 3 in 2 18 esophageal lesions at different stages (basal cell proliferation, dysplasia and esophageal cancer). Results The positive rate of p53 expression was 41 84% in basal cell hyperplasia, 73 85% in atypical hyperplasia and 75% in esophageal cancer. Among the cases of basal cell hyperplasia, 86 44% were positive for “+”, 58 + 33% for “+” positive for atypical hyperplasia, and 41.67% were positive for “+ +”. The expression level of p5 3 in esophageal cancer Above “+ +”, and 55.5% of cases were positive for “+ + + +” positive. Conclusions The expression of p5 3 protein exists in premalignant esophageal precancerous lesions, especially in benign hyperplasia stage. This may be due to damage-induced expression of intracellular wild-type p5 3 protein. The positive expression of p5 3 protein can not be regarded as malignant transformation The inevitable trend.