论文部分内容阅读
目的:探讨喉鳞状细胞癌组织中Galectin-3和血管内皮生长因子(VEGF)蛋白表达及其在肿瘤分化,生长及转移中的相关意义。方法:应用免疫组织化学SP法和免疫印记法分别对29例喉鳞状细胞癌、18例喉良性病变组织中Galectin-3和VEGF蛋白表达水平进行了检测。结果:Galectin-3(89.7%)和VEGF(86.2%)在喉鳞状细胞癌组的阳性表达率与正常对照组比较均差异有统计学意义(均P<0.05)。喉高分化鳞状细胞癌组织中Galectin-3的表达与低分化鳞状细胞癌相比差异有统计学意义(P<0.05);并且,Galectin-3与VEGF在喉鳞状细胞癌组织中的表达呈正相关关系(r=0.423,P<0.05)。结论:喉鳞状细胞癌组织中Galectin-3和VEGF的高表达可能对肿瘤的组织分化和转移起重要作用。
Objective: To investigate the expression of Galectin-3 and vascular endothelial growth factor (VEGF) in laryngeal squamous cell carcinoma and its significance in tumor differentiation, growth and metastasis. Methods: The expressions of Galectin-3 and VEGF in 29 cases of laryngeal squamous cell carcinoma and 18 cases of laryngeal benign lesions were detected by immunohistochemical SP method and immunoblotting method respectively. Results: The positive rate of Galectin-3 (89.7%) and VEGF (86.2%) in laryngeal squamous cell carcinoma was significantly lower than that in normal control (all P <0.05). The expression of Galectin-3 in laryngeal well differentiated squamous cell carcinoma was significantly lower than that in poorly differentiated squamous cell carcinoma (P <0.05). Moreover, the expression of Galectin-3 and VEGF in laryngeal squamous cell carcinoma The expression was positively correlated (r = 0.423, P <0.05). Conclusion: The high expression of Galectin-3 and VEGF in laryngeal squamous cell carcinoma may play an important role in tumor differentiation and metastasis.