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用流式细胞仪观测一定剂量视黄酸（ＲＡ）对淋巴细胞膜白介素２受体α链（ＩＬ—２Ｒα）及铁传递蛋白受体（ＴｆＲ）表达及淋巴细胞细胞周期相细胞分布特征的影响，同时测定淋巴细胞增殖功能和（４５）Ｃα内流。结果显示：１＞ＲＡ在２．５×１０（－５）～２．５×１０（－７）ｍｏｌ／Ｌ剂量范围内能促进入外周血淋巴细胞膜ＩＬ—２Ｒａ、ＴｆＲ表达，２．５×１０（－６）ｍｏｌ／Ｌ作用最明显，２．５×１０（－４）ｍｏｌ／Ｌ则对ＩＬ—２Ｒα、ＴｆＲ表达有一定抑制作用；２＞２．５×１０（－６）～２．５×１０（－７）ｍｏｌ／ＬＲＡ能促进ＰＨＡ诱导的淋巴细胞增殖，Ｇ２＋Ｍ期和Ｓ期细胞较溶剂对照明显增多，而２．５×１０（－４）ｍｏｌ／ＬＲＡ作用后，细胞多停留在Ｇ０／Ｇ１期；３＞高浓度ＲＡ（２．５×１０（－４）ｍｏｌ／Ｌ）能抑制淋巴细胞（４５）Ｃａ内流，而一定浓度（２．５×１０（－６）ｍｏｌ／Ｌ）ＲＡ则能促进（４５）Ｃａ内流。
The effects of certain doses of retinoic acid (RA) on the expression of interleukin 2 receptor alpha (IL-2Rα) and transferrin receptor (TfR) and the distribution characteristics of lymphocyte cell cycle phase cells in lymphocytes were observed by flow cytometry. Lymphocyte proliferation and (45) C alpha influx were also determined simultaneously. The results showed that 1> RA could promote the expression of IL-2Ra and TfR in peripheral blood lymphocytes in the dose range of 2.5 × 10 (-5) ~ 2.5 × 10 (-7) mol / The effect of 10 (-6) mol / L was the most obvious, 2.5 × 10 (-4) mol / L inhibited the expression of IL-2Rα and TfR. .5 × 10 (-7) mol / LRA could promote the proliferation of PHA-induced lymphocytes, while the cells in G2 + M phase and S phase increased significantly compared with the solvent control. However, after 2.5 × 10 (-4) mol / (2.5 × 10 (-4) mol / L) inhibited the influx of (45) Ca in lymphocytes, while the concentration of 2.5 × 10 (-6) mol / L) RA can promote (45) Ca influx.