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目的探讨依那普利联合美托洛尔对慢性心力衰竭患者的疗效和安全性。方法选择慢性心力衰竭患者160例,随机分为对照组和治疗组各80例,对照组只用依那普利,治疗组在应用依那普利的基础上加用美托洛尔,治疗1年,观察两组对患者症状、心功能的影响。结果治疗组比对照组左心室射血参数升高,左心室收缩末期容积下降,两组比较有统计学意义(P<0.01),治疗组治疗前后比较,左心室舒张末期容积下降(P<0.05)。结论慢性心力衰竭患者在依那普利及常规治疗基础上,应用美托洛尔能显著改善慢性心力衰竭患者的症状及心功能。
Objective To investigate the efficacy and safety of enalaprol combined with metoprolol in patients with chronic heart failure. Methods 160 patients with chronic heart failure were randomly divided into control group and treatment group 80 cases, the control group only enalapril, the treatment group based on the application of enalapril metoprolol, treatment 1 Years, observe the two groups of patients with symptoms, cardiac function. Results Compared with the control group, the left ventricular ejection fraction increased and the volume of left ventricular end-systolic volume decreased in the treatment group (P <0.01). The volume of left ventricular end-diastolic volume decreased in the treatment group before and after treatment (P <0.05 ). Conclusion Metoprolol can significantly improve the symptoms and cardiac function in patients with chronic heart failure on the basis of enalapril and conventional treatment.