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目的:分析新疆地区维吾尔族与汉族胃印戒细胞癌(SRC)临床病理与生活情况之间的差异,并对维族胃SRC的预后影响因素进行分析。方法:收集新疆医科大学附属肿瘤医院2009年1月至2015年1月收治的胃SRC患者120例,其中维吾尔族57例,汉族63例,对维、汉族患者的性别、年龄、肿瘤部位、大小、浸润深度、淋巴结转移、远处转移及术后中位进展时间、生活率进行比较。对维吾尔族胃SRC患者的临床病理指标与预后的关系进行分析。结果:两组的发病年龄、淋巴结转移、远处转移及术后中位进展时间,差异具有统计学意义(P<0.05),在性别、肿瘤部位、大小、浸润深度及术后生活率,差异无统计学意义(P>0.05)。结论:(1)与汉族相比,维族发病年龄早,淋巴结及远处转移多,术后中位进展时间早,进展风险高。(2)多因素分析显示,维族患者的性别、淋巴结N、浸润深度T是判断其预后的重要指标。
Objective: To analyze the difference between the clinical pathology and the living conditions of gastric signet ring cell carcinoma (SRC) between Uygur and Han nationalities in Xinjiang and to analyze the prognostic factors of Uighur SRC. Methods: A total of 120 patients with gastric SRC admitted from January 2009 to January 2015 in Cancer Hospital Affiliated to Xinjiang Medical University were enrolled. Among them, 57 cases were Uygur and 63 cases were Han ethnicity. Their gender, age, tumor location, size , Depth of invasion, lymph node metastasis, distant metastasis and postoperative median progression time and life rate were compared. The relationship between the clinicopathological parameters and the prognosis of gastric SRC in Uighur was analyzed. Results: There were significant differences in age, lymph node metastasis, distant metastasis and postoperative median progression time between the two groups (P <0.05). There were significant differences in sex, tumor location, size, depth of invasion and postoperative survival rate No statistical significance (P> 0.05). Conclusions: (1) Compared with Han people, Uighurs have early onset, more lymph nodes and distant metastasis, early postoperative median progression time and high risk of progression. (2) Multivariate analysis showed that the gender, lymph node N, infiltration depth T of Uygur patients are important indexes to judge their prognosis.