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目的:研究发酵虫草菌粉在慢性马兜铃酸肾病患者肾小管功能恢复中的作用。方法:33例住院慢性马兜铃酸肾病患者。予发酵虫草菌粉治疗。分别于用药前、用药1个月、3个月、6个月观察患者的尿β_2-MG、NAG、禁水尿渗透压、尿比重、肾性尿糖、SCr、CCr、夜尿量进行分析比对。结果:治疗6个月,除尿β_2-MG、NAG下降、禁水尿渗透压、尿比重增高、肾性尿糖减少继续较治疗前有明显变化外,夜尿量明显减少,反映肾功能的指标SCr、CCr也较治疗前有显著改善。结论:虫草菌粉对慢性马兜铃酸肾病患者肾小管功能具有修复作用,对延缓肾功能进展具有一定的作用。
Objective: To study the role of fermented cordyceps powder in the recovery of renal tubular function in patients with chronic aristolochic acid nephropathy. Methods: Thirty-three patients with chronic aristolochic acid nephropathy were hospitalized. To ferment Cordyceps powder treatment. Observe the urinary β_2-MG, NAG, osmotic pressure, urine specific gravity, renal urine glucose, SCr, CCr, nocturia of the patient before treatment and 1 month, 3 months and 6 months of treatment respectively. Comparison. RESULTS: After 6 months of treatment, except for the decrease of urinary β2-MG, NAG, urinary osmotic pressure, increased urine specific gravity, and reduced renal urine glucose, the night urine output decreased significantly, reflecting the renal function. The indicators SCr and CCr were also significantly improved before treatment. Conclusion: Cordyceps powder has a repairing effect on renal tubular function in patients with chronic aristolochic acid nephropathy, and it has a certain effect on delaying the progression of renal function.