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目的观察醋酸甲地孕酮(MA)在预防腹部及盆腔放疗引起的消化道反应中的作用。方法收集2008年1月至2009年12月病理学和/或细胞学证实的消化道恶性肿瘤辅助性放疗60例,采用对照研究,随机分为A和B两组。A组辅助放疗期间及放疗后1周加用MA;B组给予单纯辅助性放射治疗,观察二组放疗引起的消化道反应的差异。结果放疗同时配合使用MA厌食、恶心、呕吐发生率下降(P<0.05);厌食、恶心、呕吐程度改善(P<0.001)。结论腹部及盆腔放疗同时配合使用MA可以改善患者的厌食、恶心、呕吐反应。
Objective To observe the role of megestrol acetate (MA) in the prevention of gastrointestinal reactions caused by abdominal and pelvic radiotherapy. Methods Sixty cases of adjuvant radiotherapy of gastrointestinal malignant tumors confirmed by pathology and / or cytology from January 2008 to December 2009 were collected and randomly divided into A and B groups. Group A received MA during the adjuvant radiotherapy and 1 week after radiotherapy; Group B received simple adjuvant radiotherapy to observe the difference of gastrointestinal reactions caused by radiotherapy in the two groups. Results The incidence of anorexia, nausea and vomiting decreased with the concurrent use of radiotherapy (P <0.05). The anorexia, nausea and vomiting were improved (P <0.001). Conclusion Abdominal and pelvic radiotherapy combined with MA can improve the patient’s anorexia, nausea and vomiting.