急性冠脉综合征 ,包括不稳定心绞痛、急性心肌梗死和心源性猝死 ,是由于不稳定的冠状动脉粥样硬化斑块出现裂缝、溃疡或破裂所致。基质金属蛋白酶 (MMPs)是一类分解细胞外基质成分的锌蛋白酶 ,大量证据提示 ,动脉粥样硬化斑块破裂与MMPs降解细胞外基质有关。本文对MMPs与冠状动脉粥样硬化斑块破裂关系的研究进展进行概述 Acute coronary syndromes, including unstable angina, acute myocardial infarction and sudden cardiac death, are caused by the presence of cracks, ulcers or ruptures in unstable coronary atherosclerotic plaque. Matrix metalloproteinases (MMPs) are a type of zinc protease that decomposes extracellular matrix components. There is ample evidence that atherosclerotic plaque ruptures are associated with the degradation of extracellular matrix by MMPs. This article summarizes the research progress of MMPs and coronary atherosclerotic plaque rupture