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目的探讨糖尿病患者载脂蛋白E(ApoE)基因多态性与我国人群2型糖尿病肾病(DN)发生的相关性。方法检索2008年6月以前ApoE基因多态性与DN相关性的相关文献,用Meta分析方法评估文献的发表偏倚,计算各项研究总的OR值。结果与E3/3基因型携带者比较,携带E2/2、E3/2的T2DM患者发生DN的危险性OR值(95%CI)分别为2.16(1.04～4.83)、1.92(1.47～2.51)。与ε3等位基因比较,携带ε2等位基因T2DM患者发生DN的危险性OR为1.76(1.41～2.19)。结论ApoE基因多态性与DN相关,其中E2/2、E3/2基因型、ε2等位基因可能是我国人群2型糖尿病患者发生DN的风险因子。
Objective To investigate the association between the polymorphism of apolipoprotein E (ApoE) and the occurrence of type 2 diabetic nephropathy (DN) in Chinese population. Methods The literature about the correlation between ApoE gene polymorphism and DN before June 2008 was searched. The publication bias was evaluated by Meta analysis, and the total OR value of each study was calculated. Results Compared with E3 / 3 genotype carriers, the odds ratio (95% CI) of DN occurrence in T2DM patients with E2 / 2 and E3 / 2 were 2.16 (1.04-4.83) and 1.92 (1.47-2.51), respectively. Compared with the ε3 allele, risk of DN in patients with ε2 allele T2DM was 1.76 (range, 1.41 to 2.19). Conclusions ApoE gene polymorphism is associated with DN. The E2 / 2, E3 / 2 genotype and ε2 allele may be the risk factors of DN in type 2 diabetes mellitus in China.