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目的 探讨联合化疗与力尔凡同时应用时对造血系统的影响。方法 3 5例造血系统恶性肿瘤及实体瘤患者 ,中位年龄 3 2岁 (17～ 64岁 ) ,力尔凡与联合化疗同时应用 ,力尔凡剂量为 10mg/d ,连用 5天 ,5天后为 2 0mg/d ,连用至 2 8天 ,动态观察血象及骨髓象变化 ,评价疗效。结果 力尔凡组外周血WBC、ANC及Plat最低值均高于对照组 (P <0 0 1) ,粒细胞造血恢复时间短于对照组 (P <0 0 1) ,对红细胞的影响不明显。结论 力尔凡与联合化疗同时应用可减少对造血系统的毒副作用
Objective To investigate the effect of combination chemotherapy and Li Erfan on hematopoietic system. Methods Twenty-five patients with hematopoietic malignancies and solid tumors with a median age of 32 years (range, 17-64 years) were enrolled in this study. Each dose was administered at a dose of 10 mg / d for 5 days and 5 days 20mg / d, used up to 28 days, the dynamic observation of blood and bone marrow changes, evaluate the efficacy. Results The lowest values of WBC, ANC and Plat in peripheral blood of Li’erfan group were higher than those of the control group (P <0.01), the recovery time of hematopoietic cells was shorter than that of the control group (P <0.01), and the effect on erythrocytes was not obvious . Conclusions Li Er Fan combined with chemotherapy can reduce the side effects of hematopoietic system