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缺血/再灌注(I/R)肺损伤可见于肺组织本身和肺外组织器官I/R导致肺损伤,是指缺血所致肺损伤在血流恢复后,肺损伤不但没有减轻反而加重的现象。肺组织对I/R注非常敏感,缺血及缺血后的血液再灌注不但能造成肺组织代谢紊乱和功能障碍,还可以对其结构造成破坏,而且由I/R注引起肺组织的损伤往往出现的较早。I/R肺损伤的病理、生理机制尚不清楚,近年来I/R肺损伤越来越来受到重视,其发生、发展机制的研究也成为外科领域的热点课题之一。
Ischemia / reperfusion (I / R) lung injury can be seen in lung tissue itself and pulmonary extra-pulmonary tissue I / R-induced lung injury, is caused by ischemia-induced lung injury in the blood flow recovery, lung injury not only did not reduce but on the contrary increased The phenomenon. Lung tissue is very sensitive to I / R injection, ischemia and ischemic reperfusion of blood can not only cause metabolic disorders and dysfunction of the lung tissue, but also damage its structure, and lung damage caused by I / R injection Often appear earlier. Pathological and physiological mechanisms of I / R lung injury are not yet clear. In recent years, I / R lung injury has drawn more and more attention. The study of its occurrence and development mechanism has also become one of the hot topics in the surgical field.