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目的了解宫颈癌组织间插植放疗的研究现状,对比分析国内外不同插植模式的应用。方法检索PubMed、EMBASE、Web of Science、Cochrane Library(2015年12期)、中国生物医学文献数据库(CBM)、中国知网(CNKI)和万方数据库,检索时间均为建库至2015年12月31日。全面收集有关宫颈癌组织间插植近距离放疗的临床研究,由两名评价员分别进行文献筛选,并按照预先设计的资料提取表进行资料提取。结果共纳入85篇研究,英文35篇,中文50篇,其中24.7%(21/85)研究为临床对照研究。英文研究第一作者国家主要集中在美国(13/35)和印度(6/35),而中文研究主要分布于广州(10/50)和江苏(7/50)。中文文献来自43种期刊,仅18%(9/50)被中国科学引文数据库(CSCD)收录。随访时间、插植相关特征、治疗引导方式等报告率较低。大多研究(60/68)采用高剂量率(high dose rate,HDR)近距离治疗,采用的插植模式多达11种。32%(8/25)英文文献采用单次剂量5.5~6 Gy,每天两次,5~6次,均为会阴模板全麻下插植,而53.1%(17/32)的中文文献采用单次剂量8~12 Gy,每周1次,1~3次,均为徒手插植。结论宫颈癌组织间插植放疗研究的临床特征报告率较低,尤其是中文文献,同时对照研究数量较少。中英文研究组织间插植模式多样,无论是插植剂量,还是插植模板、麻醉方式均存在明显的差异。
Objective To understand the research status of cervical cancer tissue implantation and radiotherapy and compare the application of different implantation patterns at home and abroad. Methods PubMed, EMBASE, Web of Science, Cochrane Library (2015 issue 12), CBM, CNKI and Wanfang databases were searched. The search time was from the database to December 2015 31 days. Comprehensive collection of cervical cancer tissue interstitial brachytherapy clinical research, two reviewers were screened, and in accordance with pre-designed data extraction table for data extraction. Results A total of 85 studies were included, 35 in English and 50 in Chinese. Among them, 24.7% (21/85) were clinical controlled studies. The primary authors of English studies are mainly in the United States (13/35) and India (6/35), while Chinese studies are mainly in Guangzhou (10/50) and Jiangsu (7/50). Chinese literature comes from 43 journals, while only 18% (9/50) are included in the Chinese Science Citation Database (CSCD). Follow-up time, implants related features, treatment guidance, etc. reporting rate is low. Most studies (60/68) used high-dose rate (HDR) brachytherapy with as many as 11 implant modes. 32% (8/25) English literature using a single dose of 5.5 ~ 6 Gy, twice a day, 5 to 6 times, are perineal template under general anesthesia, and 53.1% (17/32) of the Chinese literature using a single The dose of 8 ~ 12 Gy, once a week, 1 to 3 times, are hand implanted. Conclusions There is a low rate of reporting of clinical features of cervical cancer tissue interstitial radiotherapy, especially in Chinese literature, while the number of controlled studies is small. There are many differences in the modes of anesthesia between the study groups in both English and Chinese.