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目的：研究星形细胞上调基因1（）和钙黏附蛋白E（E- cad）在食管癌中的表达的相关性，并分析与临床病理特征的关系。方法采用免疫组织化学方法和Western blot两种方法检测58例食管癌组织及其相应的癌旁组织中和钙黏附蛋白E的表达，并分析与临床病理特征的相关性。结果在58例食管癌组织中表达的阳性率82.7%明显高于相应的癌旁组织的51.7%（0.05），而与肿瘤分化程度、浸润深度、临床分期、淋巴结转移相关（<0.05）；在58例食管癌组织中钙黏附蛋白E的阳性率为31%，明显低于相应癌旁组织的94.8%（0.05），而与肿瘤分化程度、浸润深度、临床分期、淋巴结转移相关（<0.05）；食管癌中与钙黏附蛋白E的表达呈明显的负相关（=-0.483，<0.05）。结论和钙黏附蛋白E在食管癌中的表达分别表现为高表达和表达缺失，且两者与食管癌的侵润、转移密切相关，可能介导食管癌中钙黏附蛋白E的表达下调。“,”Objective To explore the correlationship of astrocyte elevated gene 1 ( ) and expression of E-cadherin (E-cad) protein in esophageal carcinoma, and analyze its relationship with clinical pathological features. Methods Immunohistochemical and Western Blot test methods were used to detect the expression of and E-cadherin protein in 58 cases of esophageal carcinoma tissues and its corresponding adjacent tissues. Then we analyzed the relationship of , E-cadherin and clinicopathologic correlation. Results In 58 cases of esophageal carcinoma tissues, the positive expression rate of was 82.7 %;The positive expression rate of was 51.7% in the corresponding adjacent tissues, the positive expression rate of in esophageal carcinoma tissues was obviously higher than that in the corresponding adjacent tissues ( < 0.05), and the expression positive rate of in esophageal carcinoma tissues was related to differentiated degree, depth of invasion, clinical stage, and lymph node metastasis ( 0.05); in 58 cases of esophageal carcinoma tissues, the positive expression rate of E-cadherin protein was 31%, the positive expression rate of E-cadherin was 94.8%;the positive expression rate of E-cadherin in esophageal carcinoma tissues was obviously less than that in the corresponding adjacent tissues ( < 0.05); It is related to differentiated degree, depth of invasion, clinical stage, and lymph node metastasis ( 0.05); the expression of and E-cadherin protein was significantly negative correlation ( = 0.483, < 0.05). Conclusions The expression of and E-cadherin in esophageal carcinoma was characterized by over-expression and loss-expression, and they were closely associated with invasion and metastasis of esophageal carcinoma, may be mediated E-cadherin less-expression in esophageal carcinoma.