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1965年 Rowe 等从一例骨髓瘤病人的血清中发现了免疫球蛋白 D(IgD)。此后许多学者相继证明了 IgD 型骨髓瘤及正常人血清中的IgD。但关于血清 IgD 的免疫学功能所知甚少。1972年 Boxel 发现正常人周围血淋巴细胞膜上有 IgD,有膜 IgD 的淋巴细胞在有膜免疫球旦白的淋巴细胞中的百分数远远超过血
In 1965 Rowe et al. Found immunoglobulin D (IgD) from the serum of a patient with myeloma. Since then, many scholars have successively demonstrated IgD in IgD-type myeloma and normal human serum. Little is known about the immunological function of serum IgD. In 1972, Boxel found that there was IgD in the membrane of peripheral blood lymphocytes in normal people, and the percentage of lymphocytes with membrane IgD in lymphocytes with membrane immunoglobulin far exceeded the blood