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The receptor-like kinase (RLK) FERONIA (FER) and its peptide ligands, called RALFs (Rapid ALkalinization Factors), function as signaling modules to control plant growth and development,stress responses, and plant immunity.Interestingly, the fungal pathogen, Fusarium oxysporum, can produce RALF mimics that interact with plant FER to promote fungal infection and multiplication (Masachis et al., 2016).Plant-parasitic nematodes such as root-knot nematodes (RKNs) cause worldwide crop damage;however, whether RNKs encode RALF peptide mimics and how they may facilitate RKN infection of host plants remain unclear.