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目的比较丁桂活络膏与其改良剂型丁桂凝胶膏剂的体外释放及透皮特性。方法分别采用微孔滤膜或Strat-M膜及改进的Franz扩散池进行体外释放及透皮试验,用HPLC法定量分析制剂中君药羌活的有效成分羌活醇的量,测定2种剂型的体外释放度、透皮量及透皮率。结果丁桂凝胶膏剂的透皮方程为=9.208-18.50,=0.948,体外累积释放度、透皮量、透皮率分别为85.34%、0.661 8 mg/g、65.67%;丁桂活络膏的透皮方程为=4.285-6.704,=0.977,体外累积释放度、透皮量、透皮率分别为67.87%、0.181 6 mg/g、31.35%。结论丁桂凝胶膏剂的体外释放度、透皮量及透皮率均优于丁桂活络膏,透皮特性明显优于原剂型,且凝胶膏剂不易过敏,贴敷方便。
OBJECTIVE To compare the in vitro release and transdermal properties of Ding Gui Huo Luo Ning Gel and its modified Ding Ding Gel Gel. Methods Microporous membrane or Strat-M membrane and modified Franz diffusion cell were respectively used for in vitro release and transdermal test. Quantitative analysis of the effective components of notonedin in Rhizoma et Radix Notopterygii by HPLC was carried out. Release, transdermal volume and transdermal rate. Results The transdermal equation of Ding Gui Gel Gel was = 9.208-18.50, = 0.948, the cumulative release in vitro, transdermal volume and transdermal rate were 85.34%, 0.661 8 mg / g, 65.67% The equation was = 4.285-6.704, = 0.977. The cumulative release in vitro, transdermal volume and transdermal rate were 67.87%, 0.181 6 mg / g and 31.35% respectively. Conclusion The in vitro release rate, transdermal volume and transdermal rate of Dinggui gel plaster are better than that of Dingguihuoxueling plaster. The transdermal properties of Dinggui gel plaster are obviously better than those of the original dosage form. The gel plaster is not easy to be allergic and easy to attach.